Phenothiazines and structurally related drugs
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Phenothiazines and structurally related drugs [proceedings] by International Symposium on Phenothiazines and Structurally Related Drugs (3rd 1973 National Institute of Mental Health (U.S.))

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Published by Raven Press in New York .
Written in English

Subjects:

  • Phenothiazine -- Congresses.,
  • Chlorpromazine -- Congresses.,
  • Thioxanthene -- Congresses.

Book details:

Edition Notes

Includes bibliographical references.

StatementEditors: Irene S. Forrest, C. Jelleff Carr [and] Earl Usdin.
SeriesAdvances in biochemical psychopharmacology,, v. 9
ContributionsForrest, Irene S., ed., Carr, C. Jelleff 1910- ed., Usdin, Earl, ed.
Classifications
LC ClassificationsRM315 .A4 vol. 9, RM666.P52 .A4 vol. 9
The Physical Object
Paginationxxii, 818 p.
Number of Pages818
ID Numbers
Open LibraryOL5439361M
ISBN 100911216618
LC Control Number73088571

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Chlorpromazine is the prototype of phenothiazines, and is structurally related to promethazine, which is used as an antihistaminic. Phenothiazines block the dopamine receptors in the basal ganglia, the hypothalamus, and the limbic system. Due to their effect on dopamine metabolism, they may cause extrapyramidal effects. Phenothiazines and structurally related drugs: Basic and clinical studies: proceedings of the 4th International Symposium on Phenothiazines and , (Developments in neuroscience) on *FREE* shipping on qualifying : Hardcover. Get this from a library! Phenothiazines and structurally related drugs: basic and clinical studies: proceedings of the 4th International Symposium on Phenothiazines and Structurally Related Drugs, held in Zurich, Switzerland, September , [Earl Usdin; Helmut Eckert; Irene S . Phenothiazine antipsychotics are medications used to treat schizophrenia and manifestations of psychotic phenothiazine antipsychotics, like prochlorperazine and chlorpromazine, are used for nausea, vomiting, and hiccups. Although, the exact mechanism of phenothiazine antipsychotics is unknown, scientists believe that they may work by blocking the .

A set of 40 phenothiazines, thioxanthenes, and structurally related drugs with multidrug resistance modulating activity in tumor cells in vitro were selected from literature data and subjected to three-dimensional quantitative structure−activity relationship study using comparative molecular field analysis (CoMFA). More than CoMFA models were derived and evaluated using steric Cited by:   For personal accounts OR managers of institutional accounts. Username *. Password *Author: J. S. Gillespie. 1. Author(s): Eckert,Helmut; Forrest,Irene S; Usdin,Earl; International Symposium on Phenothiazines and Related Drugs,(4th: Zürich); International Symposium on Phenothiazines and Structurally Related Drugs,(3d: National Institute of Mental Health) Title(s): Phenothiazines and structurally related drugs: basic and clinical studies: proceedings . Book reviewed in this article: Phenothiazines and Structurally Related Drugs. Advances in Biochemical Psycho‐pharmacology, Vol. 9. I. S. Forrest, C. J. Carr, and E.

Phenothiazine, abbreviated PTZ, is an organic compound that has the formula S(C 6 H 4) 2 NH and is related to the thiazine-class of heterocyclic tives of phenothiazine are highly bioactive and have widespread use and rich history. The derivatives chlorpromazine and promethazine revolutionized the field of psychiatry and allergy treatment, ance: greenish-yellow rhombic leaflets or diamond-shaped plates. Phenothiazines and structurally related compounds alongside their other biological activities are able to modulate multidrug resistance (MDR) in tumor cells. The extensive investigations on their MDR modulation effects consist part of the efforts to overcome MDR - the major obstacle in cancer by: Phenothiazines are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. Some are used also to control agitation in certain patients, severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients. Chlorpromazine is used also in the treatment of.   WARNING. Increased Mortality in Elderly Patients with Dementia-Related Psychosis. Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in .